Toxicology

The BASi toxicology laboratory is an AAALAC-accredited facility located on a 52-acre rural campus in southern Indiana. With an exemplary regulatory history and a combination of dedicated and experienced staff plus state-of-the-art facilities and on-line data acquisition, BASi provides clients with fast, reliable, preclinical in-life and pathological data in compliance with GLPs and other federal guidelines. Clinical pathology, analytical chemistry, and histopathology laboratories offer in-house assessment of biological samples and test articles.

Toxicology Services

• General toxicology services
  • Acute
  • Sub-chronic
  • Chronic
• Carcinogenicity studies
• Behavioral toxicology
• Immunotoxicology and biomarkers

Supporting Capabilities

• Clinical chemistry and pathology panels
• Necropsy and histology with special stains
• Dosage/diet preparation and dosage verification
• Analytical method development and validation
• Pharmacokinetics and drug metabolism           

Special Services

• Infusions of all kinds
• Biomaterial implants
• Medical device testing
• Mucosa irritation tests
• Dermal studies, including wound healing
• Ocular studies
• Vaccine studies

Clinical Pathology Capabilities

On-site capabilities include

• Hematology
• Serum chemistry
• Urinalysis
• Coagulation
• Biomarkers

The results from the Bayer Advia 120 and 1650 instruments and the Diagnostic Stago compact analyzer are interfaced into the validated state-of-the-art ToxData computer system.

Necropsy & Histopathology Capabilities

Fully equipped necropsy suites are adjacent to a high volume histopathology laboratory with QC support. The laboratory is staffed with experienced, certified histology technicians who have the training and capability to provide special stains of tissues.

Contracts with Experimental Pathology Laboratories (EPL) provide a board-certified (Diplomate, ACVP) veterinary (DVM, PhD) pathologist on site. This also allows BASi to draw on the total pathology resources of EPL when needed for high workload periods and for expedited requests.

Dosing Capabilities

All routes of administration

• Oral (gavage and admix)
• Dermal/transdermal
• Intravenous (bolus and infusion)
• Intraperitoneal
• Intravitreous
• Sub-Q
• Intrarectal or intravaginal
• Device implantation

Species

• Animal models from rodents to non-human primates

The BASi Edge

• Impeccable regulatory history
• Metrics verify 100% on-time reports for the last two years
• Scientist-to-scientist communication

Data & Reports

• Real-time secure viewing of data and results, direct communication with client
• 21 CFR Part 11-compliant
• Quality assurance audits
• Flexible report formatting, customized to sponsor's request

Licenses, Registrations, Accreditations & Memberships

• AAALAC Accreditation
• NIH Assurance
• DEA License
• USDA Inspected and registered
• Society of Toxicology (SOT), Associate Member
• American College of Toxicology (ACT), Associate Member

Consultants (each boarded in their specialty)

• Pathology - anatomical and clinical
• Veterinary ophthalmology
• Biochemistry
• Cardiology
• Statistics
• Pharmacokinetics
• Ultrasonography
• Parasitology
• Neurology
• Gastroenterology

Copyright © 2008 Bioanalytical Systems, Inc. All Rights Reserved